A novel, validated method to quantify breast cancer-related lymphedema (BCRL) following bilateral breast surgery.
Identifieur interne : 003939 ( Main/Exploration ); précédent : 003938; suivant : 003940A novel, validated method to quantify breast cancer-related lymphedema (BCRL) following bilateral breast surgery.
Auteurs : C L Miller [États-Unis] ; M C Specht [États-Unis] ; N. Horick [États-Unis] ; M N Skolny [États-Unis] ; L S Jammallo [États-Unis] ; J. O'Toole [États-Unis] ; A G Taghian [États-Unis]Source :
- Lymphology [ 0024-7766 ] ; 2013.
Descripteurs français
- KwdFr :
- Adulte, Adulte d'âge moyen, Association thérapeutique, Facteurs de risque, Femelle, Humains, Lymphoedème (anatomopathologie), Lymphoedème (étiologie), Mastectomie, Membre supérieur (anatomopathologie), Poids du corps, Sujet âgé, Tumeurs du sein (), Tumeurs du sein (radiothérapie), Tumeurs du sein (traitement médicamenteux).
- MESH :
- anatomopathologie : Lymphoedème, Membre supérieur.
- radiothérapie : Tumeurs du sein.
- traitement médicamenteux : Tumeurs du sein.
- étiologie : Lymphoedème.
- Adulte, Adulte d'âge moyen, Association thérapeutique, Facteurs de risque, Femelle, Humains, Mastectomie, Poids du corps, Sujet âgé, Tumeurs du sein.
English descriptors
- KwdEn :
- MESH :
- drug therapy : Breast Neoplasms.
- etiology : Lymphedema.
- pathology : Lymphedema, Upper Extremity.
- radiotherapy : Breast Neoplasms.
- surgery : Breast Neoplasms.
- Adult, Aged, Body Weight, Combined Modality Therapy, Female, Humans, Mastectomy, Middle Aged, Risk Factors.
Abstract
We sought to develop a formula to quantify breast cancer-related lymphedema (BCRL) after bilateral breast surgery, which functions independently of the contralateral arm and accounts for fluctuations in patient weight. Perometer arm measurements from 265 unilateral breast surgery patients were analyzed. We assessed the relationship between change in patient weight and contralateral arm volume and developed a weight-adjusted volume change formula (WAC). The WAC formula and previously-established RVC formula were compared for classification of BCRL (> or = 10% volume increase) in unilateral breast surgery patients. We then evaluated BCRL incidence using the WAC formula in 225 bilateral mastectomy patients. Change in patient weight and contralateral arm volume demonstrated an approximately linear relationship. Weight-adjusted arm volume change (WAC) was therefore calculated as WAC = (A2*W1)/(W2*A1) - 1 where A1 is pre-operative and A2 is post-operative arm volume, and W1, W2 are the patient's corresponding weights. In the unilateral analysis, there was no significant difference in number of patients classified as having BCRL using the RVC and WAC formulas (p = 0.65). In bilateral mastectomy patients 11.1% (25/225) developed BCRL, defined as > or = 10% WAC. Independent risk factors for lymphedema included axillary lymph node dissection (ALND) and higher pre-operative BMI (p<0.05). Use of this weight-adjusted arm volume change formula should be of value for quantification of BCRL after bilateral breast surgery.
PubMed: 24354105
Affiliations:
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Horick</name><affiliation wicri:level="2"><nlm:affiliation>Department of Biostatistics, Massachusetts General Hospital, Boston, Massachusetts, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Biostatistics, Massachusetts General Hospital, Boston, Massachusetts</wicri:regionArea><placeName><region type="state">Massachusetts</region></placeName></affiliation></author><author><name sortKey="Skolny, M N" sort="Skolny, M N" uniqKey="Skolny M" first="M N" last="Skolny">M N Skolny</name><affiliation wicri:level="2"><nlm:affiliation>Department of Radiation Oncology, Massachusetts General Hospital, Boston, Massachusetts, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Radiation Oncology, Massachusetts General Hospital, Boston, Massachusetts</wicri:regionArea><placeName><region type="state">Massachusetts</region></placeName></affiliation></author><author><name sortKey="Jammallo, L S" sort="Jammallo, L S" uniqKey="Jammallo L" first="L S" last="Jammallo">L S Jammallo</name><affiliation wicri:level="2"><nlm:affiliation>Department of Radiation Oncology, Massachusetts General Hospital, Boston, Massachusetts, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Radiation Oncology, Massachusetts General Hospital, Boston, Massachusetts</wicri:regionArea><placeName><region type="state">Massachusetts</region></placeName></affiliation></author><author><name sortKey="O Toole, J" sort="O Toole, J" uniqKey="O Toole J" first="J" last="O'Toole">J. O'Toole</name><affiliation wicri:level="2"><nlm:affiliation>Department of Occupational Therapy, Massachusetts General Hospital, Boston, Massachusetts, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Occupational Therapy, Massachusetts General Hospital, Boston, Massachusetts</wicri:regionArea><placeName><region type="state">Massachusetts</region></placeName></affiliation></author><author><name sortKey="Taghian, A G" sort="Taghian, A G" uniqKey="Taghian A" first="A G" last="Taghian">A G Taghian</name><affiliation wicri:level="2"><nlm:affiliation>Department of Radiation Oncology, Massachusetts General Hospital, Boston, Massachusetts, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Radiation Oncology, Massachusetts General Hospital, Boston, Massachusetts</wicri:regionArea><placeName><region type="state">Massachusetts</region></placeName></affiliation></author></analytic><series><title level="j">Lymphology</title><idno type="ISSN">0024-7766</idno><imprint><date when="2013" type="published">2013</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Adult</term><term>Aged</term><term>Body Weight</term><term>Breast Neoplasms (drug therapy)</term><term>Breast Neoplasms (radiotherapy)</term><term>Breast Neoplasms (surgery)</term><term>Combined Modality Therapy</term><term>Female</term><term>Humans</term><term>Lymphedema (etiology)</term><term>Lymphedema (pathology)</term><term>Mastectomy</term><term>Middle Aged</term><term>Risk Factors</term><term>Upper Extremity (pathology)</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Adulte</term><term>Adulte d'âge moyen</term><term>Association thérapeutique</term><term>Facteurs de risque</term><term>Femelle</term><term>Humains</term><term>Lymphoedème (anatomopathologie)</term><term>Lymphoedème (étiologie)</term><term>Mastectomie</term><term>Membre supérieur (anatomopathologie)</term><term>Poids du corps</term><term>Sujet âgé</term><term>Tumeurs du sein ()</term><term>Tumeurs du sein (radiothérapie)</term><term>Tumeurs du sein (traitement médicamenteux)</term></keywords><keywords scheme="MESH" qualifier="anatomopathologie" xml:lang="fr"><term>Lymphoedème</term><term>Membre supérieur</term></keywords><keywords scheme="MESH" qualifier="drug therapy" xml:lang="en"><term>Breast Neoplasms</term></keywords><keywords scheme="MESH" qualifier="etiology" xml:lang="en"><term>Lymphedema</term></keywords><keywords scheme="MESH" qualifier="pathology" xml:lang="en"><term>Lymphedema</term><term>Upper Extremity</term></keywords><keywords scheme="MESH" qualifier="radiotherapy" xml:lang="en"><term>Breast Neoplasms</term></keywords><keywords scheme="MESH" qualifier="radiothérapie" xml:lang="fr"><term>Tumeurs du sein</term></keywords><keywords scheme="MESH" qualifier="surgery" xml:lang="en"><term>Breast Neoplasms</term></keywords><keywords scheme="MESH" qualifier="traitement médicamenteux" xml:lang="fr"><term>Tumeurs du sein</term></keywords><keywords scheme="MESH" qualifier="étiologie" xml:lang="fr"><term>Lymphoedème</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Adult</term><term>Aged</term><term>Body Weight</term><term>Combined Modality Therapy</term><term>Female</term><term>Humans</term><term>Mastectomy</term><term>Middle Aged</term><term>Risk Factors</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Adulte</term><term>Adulte d'âge moyen</term><term>Association thérapeutique</term><term>Facteurs de risque</term><term>Femelle</term><term>Humains</term><term>Mastectomie</term><term>Poids du corps</term><term>Sujet âgé</term><term>Tumeurs du sein</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">We sought to develop a formula to quantify breast cancer-related lymphedema (BCRL) after bilateral breast surgery, which functions independently of the contralateral arm and accounts for fluctuations in patient weight. Perometer arm measurements from 265 unilateral breast surgery patients were analyzed. We assessed the relationship between change in patient weight and contralateral arm volume and developed a weight-adjusted volume change formula (WAC). The WAC formula and previously-established RVC formula were compared for classification of BCRL (> or = 10% volume increase) in unilateral breast surgery patients. We then evaluated BCRL incidence using the WAC formula in 225 bilateral mastectomy patients. Change in patient weight and contralateral arm volume demonstrated an approximately linear relationship. Weight-adjusted arm volume change (WAC) was therefore calculated as WAC = (A2*W1)/(W2*A1) - 1 where A1 is pre-operative and A2 is post-operative arm volume, and W1, W2 are the patient's corresponding weights. In the unilateral analysis, there was no significant difference in number of patients classified as having BCRL using the RVC and WAC formulas (p = 0.65). In bilateral mastectomy patients 11.1% (25/225) developed BCRL, defined as > or = 10% WAC. Independent risk factors for lymphedema included axillary lymph node dissection (ALND) and higher pre-operative BMI (p<0.05). Use of this weight-adjusted arm volume change formula should be of value for quantification of BCRL after bilateral breast surgery.</div></front></TEI><affiliations><list><country><li>États-Unis</li></country><region><li>Massachusetts</li></region></list><tree><country name="États-Unis"><region name="Massachusetts"><name sortKey="Miller, C L" sort="Miller, C L" uniqKey="Miller C" first="C L" last="Miller">C L Miller</name></region><name sortKey="Horick, N" sort="Horick, N" uniqKey="Horick N" first="N" last="Horick">N. Horick</name><name sortKey="Jammallo, L S" sort="Jammallo, L S" uniqKey="Jammallo L" first="L S" last="Jammallo">L S Jammallo</name><name sortKey="O Toole, J" sort="O Toole, J" uniqKey="O Toole J" first="J" last="O'Toole">J. O'Toole</name><name sortKey="Skolny, M N" sort="Skolny, M N" uniqKey="Skolny M" first="M N" last="Skolny">M N Skolny</name><name sortKey="Specht, M C" sort="Specht, M C" uniqKey="Specht M" first="M C" last="Specht">M C Specht</name><name sortKey="Taghian, A G" sort="Taghian, A G" uniqKey="Taghian A" first="A G" last="Taghian">A G Taghian</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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